"Brother, is life always hard? Or..."


    "Always." Wu Mian answered Chu Zhixi with a familiar routine.


    The little girl in the killer''s not too cold is now sitting in bed, and the middle-aged uncle has become a handsome young man.


    "In the cold weather, you hide in a wind and rain proof reinforced concrete house, drink boiled water, eat flame processed food, use the fixed solar energy of the ancient life remains burning in the distance, and hold the wisdom of the earth''s life. You just encounter an invisible virus, which will change some living habits. Why is it difficult?"


    "..." Chu Zhixi looked at Wu Mian in a daze.


    "Alive, we talked about similar topics." Wu Mian lost his funeral when talking to the headmaster, and his lips rose slightly. Although Chu Zhixi thought his brother was not happy, he was very strong.


    "Even if you eat Tang Monk''s meat, you will die." Wu Mian said faintly looking at the night of Tianhe.


    "Monsters don''t eat. There are a lot of things after catching monk Tang."


    "If someone eats it, the last thing is to face death."


    "Hmm? Why don''t I remember?"


    "Yin Wenjiao. When he threw jiang liuer away, it was written in the book -- I''m afraid it''s difficult to recognize, that is, he bit his finger, wrote down a blood book, carefully opened the name of his parents and the reason for his heel, and bit off a little finger on his left foot with his mouth for verification."


    "Emmm, it''s evil, brother. Yan Wenjiao just bit off a toe, not ate it."


    "Hahaha," the story of Chen Guangrui''s taking office as the revenge newspaper of the river monk in case of disaster "was not included in the editions of journey to the West in the Ming Dynasty, and it was sandwiched between the eighth and ninth times in the Qing Dynasty." Wu Mian said with a smile, "Prince Ma said this period of careful thinking and fear, I don''t think so."


    "I''ve heard of you. It seems that Yin Wenjiao and the robber were childhood sweethearts. The robber is also the son of a rich family, otherwise he can''t be an official for more than ten years and won''t be found."


    "That''s almost what I mean." Wu Mian said, "don''t think about it. Burn your eyebrows and take care of the present. Today, the state has launched ten measures to resume work and production, and Jiangsu, Zhejiang and Tiannan have begun to resume production. Life must go on. It''s too extreme to think about."


    "Even if the virus can''t be contained, we have at least got the first hand. There is no virus in China, but it can be simpler if the imported cases of foreign defense are imported. Just sit on the wall and watch how the foreign virus mutates. The worst and worst situations also have reaction time, unlike the encounter in Tianhe City."


    "Well." Chu Zhixi nodded softly, "is there any news?"


    "The Ministry of science and technology said that chloroquine has a certain effect on new pneumonia."


    "Will it be effective? Control transcription?"


    "The negatively charged 7-chloro group on the quinoline ring is close to the 2-amino group on the guanine of DNA, so that chloroquine is inserted between the two strands of the double helix of DNA and forms a complex with DNA, thus preventing DNA replication and RNA transcription."


    "I don''t think so."


    "I don''t think so." Wu Mian smiled. "Maybe it will have a certain effect in cocktail therapy. I haven''t studied it. I don''t know. There have been a lot of relevant news recently. Everyone hopes to have specific drugs to treat new pneumonia."


    "Do you think there will be?"


    "I hope there will be." Wu Mian said faintly, looking at the dark night. "Otherwise, if the headmaster said that, the antibody will disappear quickly, and our lives will be changed in the future."


    "How to change? After we get married, we won''t want you a room and me a room." Chu Zhixi smiled at Wu Mian.


    "No, but football and basketball are high-risk projects. E-sports will get better and better? By the way, the horse Yard said that Li Yifei, the owner of Sanqi mutual entertainment, bought 200000 N95 masks. Those who make mobile games have money. They will have more money in the future."


    "Ha ha ~ ~" Chu Zhixi said with a smile, "I''m worried about the hospital."


    "Hospital, that''s it. Emergency first aid may be a lot of trouble, but you have to think about fewer nightclubs, fewer fights, less drunk driving, and relatively speaking, the life expectancy will increase."


    "Emmm, what my brother said seems reasonable, but I always think something is wrong. You must be lying to me, aren''t you?"


    "Don''t think about it. Go to bed early and I''ll study chloroquine." Wu Mian said.


    "Brother, if chloroquine is effective, will artemisinin also have an effect?"


    "The main function of artemisinin''s antimalarial mechanism is to interfere with the functions of surface membrane mitochondria of Plasmodium. Firstly, artemisinin acts on food vesicle membrane, surface membrane and mitochondria, and secondly on nuclear membrane and endoplasmic reticulum. It also has a certain impact on chromatin in the nucleus, and finally leads to the destruction of the whole structure of the parasite."


    "From the chemical formula of chloroquine and artemisinin, the aromatic ring of artemisinin has no acid radical like chloroquine phosphate, which has little interference with the genetic material of the virus. So it can be speculated that chloroquine phosphate is better than New Coronavirus in the treatment of artemisinin.


    "That''s right," Chu Zhixi said. His eyes were already closed and he fell into a sleepwalking state.


    "Good, go to bed early and go to work tomorrow. In other words, many patients in our shelter will be discharged tomorrow. We must take photos as a souvenir." Wu Mian asked.


    "You didn''t care about this kind of thing at all." Chu Zhixi said vaguely.


    "It was a peaceful age. What are you doing with these formalisms?" Wu Mian lay down with Chu Zhixi in his arms, covered her with a quilt, patted her gently, and said softly like coaxing a child. "It''s different now. Let others know any good news as soon as possible. Increase confidence and let everyone know that hope is not far away."


    "But antibodies..." Chu Zhixi said, already asleep, completely unprepared, as if he had fallen asleep the moment he closed his eyes.


    "It doesn''t matter, as long as you live," Wu Mian said gently. "If you live, there is hope."


    Gently patted Chu Zhixi to sleep. Three minutes later, Wu Mian stood up, took a look at the sleeping sweet girl, turned back, opened his notebook and began to contact the Ministry of science and technology.


    A small number of experimental studies on the therapeutic effect of chloroquine have been carried out in clinic, and about 100 patients have carried out relevant trials.


    Wu Mian receives data, looks at it bit by bit and analyzes it bit by bit.


    If only chloroquine could work, chloroquine phosphate is generally synthesized by quinoline, and quinoline is generally extracted from coal tar. Its extraction process has been relatively mature in China.


    There are also many Chinese companies that can produce quinoline.


    Not like H1N1, it has been a long time since the imitation of Tamiflu was launched.


    However, due to time constraints, all studies have been less than a month since the outbreak of the epidemic.


    Wu Mian read the literature and felt that chloroquine was not very useful.