"Mining was constantly mentioned in the Chinese Exclusion Act, because mining was profitable at that time, just like today''s chips. More than 100 years have passed, but nothing has changed." Wu Mian said, put away the B-ultrasound probe and wiped the coupling agent on gerbin mecatok with a paper towel.


    "Mr. gerbin mecatok''s abdominal organs are not a big problem," Wu Mian said. "Although his liver has a tendency of fat deposition, it doesn''t matter."


    "And then?"


    "Go for an MRI," said Wu Mian. "Mr. gerbin mecatok''s autoimmune antibodies are all negative, and it is not caused by autoimmune encephalitis.


    Excluding these diseases, if the MRI data do not show atrophy of the frontal and temporal lobes, we can drink a cup of coffee and wait for the final test results. "


    Owen Rothschild silently pushed his wheelchair and followed Wu Mian.


    Now that you have chosen to come to China to see Wu Mian, there is still some trust. Even Wu Mian repeatedly denied that gerbin mecatok was a mixture of goblins and Bigfoot monsters.


    One hour later, Wu Mian pointed to the image on the screen in the operation room and said, "Owen, Mr. gerbin mecatok has no signs of brain atrophy. His physical condition can be said to be quite good."


    "Hmm?" Owen looked at Wu Mian and waited for what he would say next.


    "But the MRI showed symmetrical abnormal signals at the bilateral internal capsule knees, bilateral internal capsule hind limbs, bilateral cerebral feet, pons and cerebellar dentate nucleus. Owen, I simply said, the MRI showed that there was a problem with the brain, but it was not Alzheimer''s disease."


    “……”


    "MRI of ankle joint showed fusiform enlargement of bilateral Achilles tendon," Wu Mian said. "The problem is here."


    "Wu, if I don''t understand wrong, can I say so," said Owen Rothschild cautiously. "Because there is something wrong with gerbin mecatok''s foot, it leads to his abnormal mental state?"


    When saying this, Owen felt extremely absurd in his heart.


    Because there is a problem with your feet, your brain is difficult to use... Is this a human word?


    But Owen nodded when he saw Wu Mian. "Owen, you are really a smart man. What you said is right. That''s what I mean."


    "..." Owen was silent.


    "The speed of genetic testing is very slow. We still have a few hours," Wu Mian said. "I suspect that Mr. gerbin mecatok has a very rare genetic disease - brain tendon xanthomatosis."


    "Brain tendon xanthomatosis?!" Ao Wen didn''t understand what kind of disease it was. He was very strange and had never heard of it.


    "According to the name, we can know what the disease is. Brain tendon means brain and tendon."


    “……”


    It''s hard for Owen Rothschild to connect the two organs.


    "This is a rare disorder of lipid metabolism. Generally speaking, it is recessive and characterized by progressive ataxia, dementia, cataract and chorioxanthoma."


    "Usually caused by CYP27A1 gene mutation, the incidence rate is one in a million parts worldwide, and the incidence rate varies from place to place.


    "Are you sure?" asked Owen Rothschild.


    "Not sure, of course not. It''s just a guess now," Wu Mian said. "We''re waiting for the results of genetic testing."


    "Is it really just a disease? Why can the brain and feet be connected?" Owen asked.


    "Patients with xanthomatosis of brain tendons cannot convert cholesterol into bile acids, and cholestanol, another metabolite of cholesterol, will become more and accumulate in the body. On the other hand, insufficient bile acids and negative feedback lead to excessive cholesterol production."


    "Wu, I know it can explain why the damn cholesterol rises," said Owen. "But it can''t explain the changes in the nervous system at all. Are you kidding? It''s not funny at all."


    "Ao Wen, there is no definite conclusion on how brain tendon xanthomatosis causes neurotoxicity and damages the nervous system. However, some people have put forward the hypothesis that a large amount of cholesterol and cholestanol will destroy the blood-brain barrier and damage the central nervous system," Wu Mian said.


    "Maybe you''re not satisfied with this explanation. Let''s wait." Wu Mian continued when he saw that Ao Wen was silent. "If the genetic test results confirm my guess, even if you don''t want to believe it, you can only accept this diagnosis."


    "Can I trust you?" Owen Rothschild looked at Wu Mian carefully and asked word by word.


    "You don''t need to trust me. Everything is based on objective examination," Wu Mian said. "The data is still poor. The last puzzle has been completed. You can send all the examinations to doctors in any hospital in the world for consultation."


    "Wu, I believe your judgment." Owen''s voice was low and distant, as if he were making a sound in the wall.


    "Owen, this is science," said Wu Mian. "The physical signs of Mr. gerbin mecatok also prove this. 70% of patients will have xanthoma tendons, and the neurological symptoms appear later and have various manifestations, including dementia, abnormal behavior, ataxia, pyramidal tract sign, epilepsy, myelopathy and peripheral neuropathy."


    Owen Rothschild was silent.


    Wu Mian said nothing more. He uploaded the image data, shut down the machine, and left the MRI room with AO Wen to wait for the final test results.


    Not surprisingly, the test results confirmed Wu Mian''s conjecture that Gebin mecatok had a CYP27A1 gene mutation.


    "Owen, I''ll send all the information to your mailbox." Wu Mian sat in front of the examination table and said seriously, "I''m sorry to tell you that Mr. gerbin mecatok''s diagnosis is very clear. It''s brain tendon xanthoma. According to your description, when he was at Harvard, the doctor wanted to make a clear diagnosis, but you and mecatok..."


    Wu Mian said and sighed.


    "Wu, how to treat it?"


    "Try it. Generally speaking, the earlier the treatment, the better the effect." Wu Mian said, "neutralize geese deoxycholic acid for Mr. gerbin mecatok. The specific effect depends on the sensitivity of his body. However, I judge from all kinds of data. I think there should be no problem."


    "Can you wake up?" Owen had a new hope.


    It would be a great thing if gerbin mecatok could wake up.


    "In terms of probability, there is 85% possibility." Wu Mian nodded. "Brain tendon xanthomatosis is a progressive disease, but it is not fatal. Even if it is not treated, it may live to 50 or 60 years old. But early detection and early treatment are more conducive to controlling neurological symptoms and easier to recover."


    Then Wu Mian paused.


    "It''s all right. You have money. As long as you have money, you can solve it!"