"Wu, I don''t want to listen to the final conclusion. Can you tell me the most critical theory?" Rodriguez asked.


    "My research, the last step - finding that the deep brain may be able to reset the unstable pattern of neuronal oscillation in Alzheimer''s patients, especially in the hippocampus θ Rhythm may play an important role in learning and memory. "


    “……”


    "Veterans don''t die, they just die slowly," Wu Mian said. "In fact, cortical cells are not dead, but the unstable pattern of neuronal concussion."


    "You have to solve it with quantum theory..." Rodriguez murmured.


    "No, it''s just inspired." Wu Mian said, "after reading the final results, you will know that the treatment is not as difficult as expected, and the key lies in positioning. And positioning depends on your genius''s idea - DST surround matrix gradient system."


    Rodriguez was silent.


    Neurons vibrate and appear unstable patterns. This way of statement and narration often appears in quantum physics.


    However, signapioneer 3.0T magnetic resonance is the product of classical physics and has nothing to do with uncertain quantum physics.


    "Rod, in our previous study, we found that the selective feeding of rats increased significantly through low-frequency electrical stimulation of large cells in bilateral basal nuclei. After electrical stimulation, neurons in prefrontal cortex, hippocampal ca1ca2ca3 and ventral dentate gyrus were activated."


    Chu Zhixi went to pick up the patient. Wu Mian took advantage of this time and said to Rodriguez, "bilateral basal nucleus large cells are related to the formation of memory, and this process is mainly realized through the projection of basal nucleus large cells to cholinergic neurons in extensive cortical areas. This view has been confirmed by many later studies."


    "Cholinergic neurons, what a wonderful word."


    "Wu, then?"


    "Then there are trade secrets." Wu Mian said with a smile.


    "..." Rodriguez really wanted to rush up and beat Wu Mian with his fist.


    If he couldn''t beat him, he would have rushed up early in the morning.


    Either don''t say it, just say it, but he said the most critical place, and then stopped abruptly! Rodriguez almost spewed out his old blood.


    "Look at you, my old friend, don''t look like that," said Wu Mian. "Then I''ll say a little more as a sincere invitation."


    "This is not an invitation, but coercion! If I come to you, I will receive a lawyer''s letter from general medical the next day!" Rodriguez said angrily.


    "Neuron proliferation - entorhinal area: after electrical stimulation of the entorhinal area in rats, it is found that it can induce the proliferation of hippocampal dentate gyrus neurons. At the same time, the spatial memory function of mice is improved, and..."


    "And what?"


    "Moreover, I found that the improvement of spatial memory function can be antagonized by temozolomide."


    Memory, this is the forbidden area of Neurology!


    Now Wu''s research has begun to touch the restricted area? And it''s not touch, but further research has been done, and even antagonists have been found.


    "Thalamic anterior nuclear stimulation can also induce the proliferation of hippocampal dentate gyrus neurons in rats. Neuron proliferation appears 24 hours after short-term electrical stimulation, reaches the peak on the third day, and can last for 4 weeks. The proliferation intensity is related to the stimulation frequency."


    "Rod, do you know what that means?"


    "I don''t know if I can treat Alzheimer''s disease. Damn it, your habit infected me. It''s Alzheimer''s disease!" Rodriguez complained and continued, "but it can prevent Alzheimer''s disease. Wu, can I understand that?"


    "Yes," said Wu Mian, "the Tang team in California first gave fornix electrical stimulation to the disease model of Rett syndrome, which can significantly improve spatial cognitive memory function and return to the level of normal animal cognitive function."


    "When did it happen?"


    "13 months ago, it was published in the journal Nature."


    Rodriguez shrugged his shoulders. He was just an engineer and would not study the basic theory too deeply.


    "In other words, deep brain electrical stimulation can promote the release of nerve growth factor; promote the proliferation of neurons in the subgranular area of the dentate gyrus; change the electrical activity of hippocampal neurons; and promote the release of acetylcholine. A theoretical pathway has formed a closed loop. As long as it can be located, we can try to treat Alzheimer''s disease."


    "It''s Alzheimer''s disease!" Rodriguez stressed.


    "It''s all the same. You know what I''m talking about," Wu Mian said. "But the research on brain networks is still at a relatively backward stage, but that''s the past. From now on, none of this exists."


    "Are you really sure?"


    "Of course, rod," said Wu Mian, "what I want to show you is the miracle of breaking the cocoon and turning into a butterfly."


    "Break the cocoon and turn into a butterfly?"


    Obviously, Rodriguez can''t understand the beauty of Chinese. Wu Mian''s words translated in English are not so flexible and vivid.


    Wu Mian did not continue to explain, but played out the previous magnetic resonance images of small vegetative patients.


    This is the full version, not the processed version that Jack Jones saw 36 hours ago.


    The activity of brain tissue below the hypothalamus is very high, but the more outward, the worse the activity. It''s like a tree, a tree standing in the cold winter of Siberia, with only trunk and some branches.


    It seems dead and lifeless.


    The three-dimensional image rotates slowly, and the gray outer layer is like a cocoon, which is empty.


    "Wu, why did you make it so exquisite? At least 30% of the system running speed was wasted!" Rodriguez complained.


    "Rod, this is business value. Not only you and I can understand it, but at least jack can understand it." Wu Mian looked at Jack Jones and said.


    "Since 1985, Professor Turnbull has used basal nuclear power stimulation to treat dementia. This is not a new operation. However, all research has stopped at positioning and has not made a breakthrough."


    "Wu, why?"


    "Because... Their surgical techniques and hazy positioning are very elementary," Wu Mian said frankly.


    "I regret what you said."


    "The targets of hypothalamus and fornix nucleus are located below the lateral ventricle and in front of the third ventricle. The implanted electrode must pass through the lateral ventricle. Because the head end of the implanted electrode is thicker and blunt than the microelectrode, after the microelectrode recording, the implanted electrode is easy to slide along the lateral ventricular wall when passing through the lateral ventricular wall, which affects the accuracy of the target."


    "It has no accuracy and is affected by surgical errors, so the effect can only be unsatisfactory. Everything is taking a chance. This is my summary of the past."